Treatment of GE in

Genetic epilepsy is a group of heterogeneous conditions caused by mutations in specific genes controlling neuronal ion channel function or brain development. ICD-10 code G40 (epilepsy), but the specific genetic syndrome is identified separately. The most significant include: Dravet syndrome (SCN1A mutations, a severe early-onset epileptic encephalopathy), Lennox-Gastaut syndrome (multiple seizure types, cognitive impairment), benign familial neonatal seizures (BFNS, KCNQ2 mutations — relatively favorable), and epilepsies with CDKL5, SCN2A, GRIN-related mutations and many others. Some are de novo, some — inherited. Clinical presentation depends on the specific syndrome: seizure types and frequency, presence of developmental delay, behavioral features, possible intellectual disability. For example, in Dravet — fever-provoked prolonged seizures in the first year, then myoclonic, atypical absences, gradual developmental delay; in Lennox-Gastaut — tonic seizures, atypical absences, drop attacks, developmental delay; in BFNS — brief neonatal seizures often resolving with age. Treatment of genetic epilepsies includes several streams. The base is antiepileptic drugs chosen for the specific syndrome (for example, in Dravet — valproate + clobazam, sodium channel blockers like carbamazepine are contraindicated). In some patients — the ketogenic diet (especially effective in Dravet, Lennox-Gastaut, GLUT1 deficiency syndrome). Specific targeted drugs are emerging — fenfluramine for Dravet, ganaxolone for CDKL5. In drug-resistant forms — vagus nerve stimulation (VNS) or surgery. Rehabilitation plays a key role in the child's development between seizures. Our Huizhou program: specialized therapeutic exercise (adapted to current condition and seizure risk), occupational therapy (daily skills and adaptive aids), speech therapy (speech stimulation), sensory integration in a calm environment (avoiding over-stimulation). This is especially important for children with severe syndromes like Dravet and Lennox-Gastaut, where developmental delay requires continuous work. Important features of our approach. **Acupuncture is used with caution** — in some children with epilepsy, stimulation of certain points may theoretically provoke seizures. The decision is made only after epileptologist consultation and under observation. **Non-stimulating** modalities — gentle massage, calm sensory environment, no abrupt changes. **100% coordination with the treating epileptologist** — we receive the discharge note, coordinate the program with the current AED regimen, and track progress. **Compatible with the ketogenic diet** — we work with a dietitian as needed. **A seizure-during-session algorithm** — all staff are trained, protocols are in place.